| Date | Time (UTC) | Home Team | Away Team |
|---|---|---|---|
| Wednesday 25th September | 15:45 | AZ Alkmaar | IF Elfsborg |
| Wednesday 25th September | 15:45 | Bodo/Glimt | FC Porto |
| Wednesday 25th September | 18:00 | Anderlecht | Ferencvaros |
| Wednesday 25th September | 18:00 | Dynamo Kiev | Lazio |
| Wednesday 25th September | 18:00 | FC Midtjylland | Hoffenheim |
| Wednesday 25th September | 18:00 | Galatasaray | PAOK Salonika |
| Wednesday 25th September | 18:00 | Ludogorets | Slavia Prague |
| Wednesday 25th September | 18:00 | Manchester United | FC Twente |
| Wednesday 25th September | 18:00 | Nice | Real Sociedad |
| Thursday 26th September | 15:45 | Fenerbahce | Union Saint-Gilloise |
| Thursday 26th September | 15:45 | Malmo FF | Rangers |
| Thursday 26th September | 18:00 | Ajax | Besiktas |
| Thursday 26th September | 18:00 | Braga | Maccabi Tel Aviv |
| Thursday 26th September | 18:00 | Eintracht Frankfurt | FC Viktoria Plzen |
| Thursday 26th September | 18:00 | FC Steaua Bucuresti | Rigas Futbola Skola |
| Thursday 26th September | 18:00 | Lyon | Olympiakos FC |
| Thursday 26th September | 18:00 | Roma | Athletic Bilbao |
| Thursday 26th September | 18:00 | Tottenham Hotspur | Qarabag FK |
| Thursday 3rd October | 15:45 | Ferencvaros | Tottenham Hotspur |
| Thursday 3rd October | 15:45 | Hoffenheim | Dynamo Kiev |
| Thursday 3rd October | 15:45 | Lazio | Nice |
| Thursday 3rd October | 15:45 | Maccabi Tel Aviv | FC Midtjylland |
| Thursday 3rd October | 15:45 | Olympiakos FC | Braga |
| Thursday 3rd October | 15:45 | Qarabag FK | Malmo FF |
| Thursday 3rd October | 15:45 | Real Sociedad | Anderlecht |
| Thursday 3rd October | 15:45 | Rigas Futbola Skola | Galatasaray |
| Thursday 3rd October | 15:45 | Slavia Prague | Ajax |
| Thursday 3rd October | 18:00 | Athletic Bilbao | AZ Alkmaar |
| Thursday 3rd October | 18:00 | Besiktas | Eintracht Frankfurt |
| Thursday 3rd October | 18:00 | FC Porto | Manchester United |
| Thursday 3rd October | 18:00 | FC Twente | Fenerbahce |
| Thursday 3rd October | 18:00 | FC Viktoria Plzen | Ludogorets |
| Thursday 3rd October | 18:00 | IF Elfsborg | Roma |
| Thursday 3rd October | 18:00 | PAOK Salonika | FC Steaua Bucuresti |
| Thursday 3rd October | 18:00 | Rangers | Lyon |
| Thursday 3rd October | 18:00 | Union Saint-Gilloise | Bodo/Glimt |
| Wednesday 23rd October | 13:30 | Braga | Bodo/Glimt |
| Wednesday 23rd October | 13:30 | Galatasaray | IF Elfsborg |
| Thursday 24th October | 15:45 | Eintracht Frankfurt | Rigas Futbola Skola |
| Thursday 24th October | 15:45 | FC Midtjylland | Union Saint-Gilloise |
| Thursday 24th October | 15:45 | Ferencvaros | Nice |
| Thursday 24th October | 15:45 | Maccabi Tel Aviv | Real Sociedad |
| Thursday 24th October | 15:45 | PAOK Salonika | FC Viktoria Plzen |
| Thursday 24th October | 15:45 | Qarabag FK | Ajax |
| Thursday 24th October | 15:45 | Roma | Dynamo Kiev |
| Thursday 24th October | 18:00 | Anderlecht | Ludogorets |
| Thursday 24th October | 18:00 | Athletic Bilbao | Slavia Prague |
| Thursday 24th October | 18:00 | FC Porto | Hoffenheim |
| Thursday 24th October | 18:00 | FC Twente | Lazio |
| Thursday 24th October | 18:00 | Fenerbahce | Manchester United |
| Thursday 24th October | 18:00 | Lyon | Besiktas |
| Thursday 24th October | 18:00 | Malmo FF | Olympiakos FC |
| Thursday 24th October | 18:00 | Rangers | FC Steaua Bucuresti |
| Thursday 24th October | 18:00 | Tottenham Hotspur | AZ Alkmaar |
| Wednesday 6th November | 13:30 | Besiktas | Malmo FF |
| Thursday 7th November | 15:45 | Bodo/Glimt | Qarabag FK |
| Thursday 7th November | 15:45 | Eintracht Frankfurt | Slavia Prague |
| Thursday 7th November | 15:45 | FC Steaua Bucuresti | FC Midtjylland |
| Thursday 7th November | 15:45 | Galatasaray | Tottenham Hotspur |
| Thursday 7th November | 15:45 | IF Elfsborg | Braga |
| Thursday 7th November | 15:45 | Ludogorets | Athletic Bilbao |
| Thursday 7th November | 15:45 | Nice | FC Twente |
| Thursday 7th November | 15:45 | Olympiakos FC | Rangers |
| Thursday 7th November | 15:45 | Union Saint-Gilloise | Roma |
| Thursday 7th November | 18:00 | AZ Alkmaar | Fenerbahce |
| Thursday 7th November | 18:00 | Ajax | Maccabi Tel Aviv |
| Thursday 7th November | 18:00 | Dynamo Kiev | Ferencvaros |
| Thursday 7th November | 18:00 | FC Viktoria Plzen | Real Sociedad |
| Thursday 7th November | 18:00 | Hoffenheim | Lyon |
| Thursday 7th November | 18:00 | Lazio | FC Porto |
| Thursday 7th November | 18:00 | Manchester United | PAOK Salonika |
| Thursday 7th November | 18:00 | Rigas Futbola Skola | Anderlecht |
| Thursday 28th November | 15:45 | AZ Alkmaar | Galatasaray |
| Thursday 28th November | 15:45 | Anderlecht | FC Porto |
| Thursday 28th November | 15:45 | Athletic Bilbao | IF Elfsborg |
| Thursday 28th November | 15:45 | Besiktas | Maccabi Tel Aviv |
| Thursday 28th November | 15:45 | Dynamo Kiev | FC Viktoria Plzen |
| Thursday 28th November | 15:45 | Lazio | Ludogorets |
| Thursday 28th November | 15:45 | Qarabag FK | Lyon |
| Thursday 28th November | 15:45 | Rigas Futbola Skola | PAOK Salonika |
| Thursday 28th November | 18:00 | Braga | Hoffenheim |
| Thursday 28th November | 18:00 | FC Midtjylland | Eintracht Frankfurt |
| Thursday 28th November | 18:00 | FC Steaua Bucuresti | Olympiakos FC |
| Thursday 28th November | 18:00 | FC Twente | Union Saint-Gilloise |
| Thursday 28th November | 18:00 | Ferencvaros | Malmo FF |
| Thursday 28th November | 18:00 | Manchester United | Bodo/Glimt |
| Thursday 28th November | 18:00 | Nice | Rangers |
| Thursday 28th November | 18:00 | Real Sociedad | Ajax |
| Thursday 28th November | 18:00 | Slavia Prague | Fenerbahce |
| Thursday 28th November | 18:00 | Tottenham Hotspur | Roma |
| Wednesday 11th December | 13:30 | Fenerbahce | Athletic Bilbao |
| Thursday 12th December | 15:45 | FC Viktoria Plzen | Manchester United |
| Thursday 12th December | 15:45 | Hoffenheim | FC Steaua Bucuresti |
| Thursday 12th December | 15:45 | Ludogorets | AZ Alkmaar |
| Thursday 12th December | 15:45 | Malmo FF | Galatasaray |
| Thursday 12th December | 15:45 | Olympiakos FC | FC Twente |
| Thursday 12th December | 15:45 | PAOK Salonika | Ferencvaros |
| Thursday 12th December | 15:45 | Roma | Braga |
| Thursday 12th December | 15:45 | Union Saint-Gilloise | Nice |
| Thursday 12th December | 18:00 | Ajax | Lazio |
| Thursday 12th December | 18:00 | Bodo/Glimt | Besiktas |
| Thursday 12th December | 18:00 | FC Porto | FC Midtjylland |
| Thursday 12th December | 18:00 | IF Elfsborg | Qarabag FK |
| Thursday 12th December | 18:00 | Lyon | Eintracht Frankfurt |
| Thursday 12th December | 18:00 | Maccabi Tel Aviv | Rigas Futbola Skola |
| Thursday 12th December | 18:00 | Rangers | Tottenham Hotspur |
| Thursday 12th December | 18:00 | Real Sociedad | Dynamo Kiev |
| Thursday 12th December | 18:00 | Slavia Prague | Anderlecht |
| Tuesday 21st January | 13:30 | Galatasaray | Dynamo Kiev |
| Wednesday 22nd January | 13:30 | Besiktas | Athletic Bilbao |
| Thursday 23rd January | 15:45 | AZ Alkmaar | Roma |
| Thursday 23rd January | 15:45 | Bodo/Glimt | Maccabi Tel Aviv |
| Thursday 23rd January | 15:45 | FC Porto | Olympiakos FC |
| Thursday 23rd January | 15:45 | FC Viktoria Plzen | Anderlecht |
| Thursday 23rd January | 15:45 | Fenerbahce | Lyon |
| Thursday 23rd January | 15:45 | Hoffenheim | Tottenham Hotspur |
| Thursday 23rd January | 15:45 | Malmo FF | FC Twente |
| Thursday 23rd January | 15:45 | Qarabag FK | FC Steaua Bucuresti |
| Thursday 23rd January | 18:00 | Eintracht Frankfurt | Ferencvaros |
| Thursday 23rd January | 18:00 | IF Elfsborg | Nice |
| Thursday 23rd January | 18:00 | Lazio | Real Sociedad |
| Thursday 23rd January | 18:00 | Ludogorets | FC Midtjylland |
| Thursday 23rd January | 18:00 | Manchester United | Rangers |
| Thursday 23rd January | 18:00 | PAOK Salonika | Slavia Prague |
| Thursday 23rd January | 18:00 | Rigas Futbola Skola | Ajax |
| Thursday 23rd January | 18:00 | Union Saint-Gilloise | Braga |
| Thursday 30th January | 18:00 | Ajax | Galatasaray |
| Thursday 30th January | 18:00 | Anderlecht | Hoffenheim |
| Thursday 30th January | 18:00 | Athletic Bilbao | FC Viktoria Plzen |
| Thursday 30th January | 18:00 | Braga | Lazio |
| Thursday 30th January | 18:00 | Dynamo Kiev | Rigas Futbola Skola |
| Thursday 30th January | 18:00 | FC Midtjylland | Fenerbahce |
| Thursday 30th January | 18:00 | FC Steaua Bucuresti | Manchester United |
| Thursday 30th January | 18:00 | FC Twente | Besiktas |
| Thursday 30th January | 18:00 | Ferencvaros | AZ Alkmaar |
| Thursday 30th January | 18:00 | Lyon | Ludogorets |
| Thursday 30th January | 18:00 | Maccabi Tel Aviv | FC Porto |
| Thursday 30th January | 18:00 | Nice | Bodo/Glimt |
| Thursday 30th January | 18:00 | Olympiakos FC | Qarabag FK |
| Thursday 30th January | 18:00 | Rangers | Union Saint-Gilloise |
| Thursday 30th January | 18:00 | Real Sociedad | PAOK Salonika |
| Thursday 30th January | 18:00 | Roma | Eintracht Frankfurt |
| Thursday 30th January | 18:00 | Slavia Prague | Malmo FF |
| Thursday 30th January | 18:00 | Tottenham Hotspur | IF Elfsborg |
Important
All times have been converted to UTC based on the typical time zone differences from Central European Time (CET) and Eastern European Time (EET).